Mechanical unfolding of long human telomeric RNA (TERRA).
نویسندگان
چکیده
We report the first single molecule investigation of TERRA molecules. By using optical-tweezers and other biophysical techniques, we have found that long RNA constructions of up to 25 GGGUUA repeats form higher order structures comprised of single parallel G-quadruplex blocks, which unfold at lower forces than their DNA counterparts.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 49 57 شماره
صفحات -
تاریخ انتشار 2013